› 6g5j

X-ray diffraction
1.85Å resolution

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Group 10 secretory phospholipase A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15496 (Residues: 1-165; Coverage: 100%)
Gene name: PLA2G10
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

4 bound ligands:
Ligand CA 2 x CA
Ligand EM8 3 x EM8
Ligand PEG 1 x PEG
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+
Spacegroup: P212121
Unit cell:
a: 27.962Å b: 85.501Å c: 103.079Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Recent Progress Concerning the N-Arylation of Indoles.
Oeser et al. (2021)
2 other articles

3 mentions without citation

Structural and Functional Aspects of Targeting the Secreted Human Group IIA Phospholipase A2.
Kim et al. (2020)
2 more