› 6gbd

Solution NMR

Murine Protein Tyrosine Phosphatase PTPN13 PDZ3 Domain

Released:
DOI: 10.2210/pdb6gbd/pdb
PDB entry 6gbd coloured by chain, ensemble of 20 models, front view.
PDB entry 6gbd coloured by chain, ensemble of 20 models, side view.
PDB entry 6gbd coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Molecular Basis of Class III Ligand Recognition by PDZ3 in Murine Protein Tyrosine Phosphatase PTPN13.
Kock G, Dicks M, Yip KT, Kohl B, Pütz S, Heumann R, Erdmann KS, Stoll R
J Mol Biol 430 4275-4292 (2018)
PMID: 30189200

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-563340 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 13 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 12.69 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q64512 (Residues: 1475-1588; Coverage: 5%)
Gene names: Ptp14, Ptpn13
Sequence domains: PDZ domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

The binding affinity of PTPN13's tandem PDZ2/3 domain is allosterically modulated.
Dicks et al. (2019)
1 more