› 6gc5

X-ray diffraction
1.9Å resolution

Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

Released:
DOI: 10.2210/pdb6gc5/pdb
Model geometry
Fit model/data
PDB entry 6gc5 coloured by chain, front view.
PDB entry 6gc5 coloured by chain, side view.
PDB entry 6gc5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM.
Ripin N, Boudet J, Duszczyk MM, Hinniger A, Faller M, Krepl M, Gadi A, Schneider RJ, Šponer J, Meisner-Kober NC, Allain FH
OpenAccess logo Proc Natl Acad Sci U S A 116 2935-2944 (2019)
PMID: 30718402

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172381 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
ELAV-like protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 90 amino acids
Theoretical weight: 9.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15717 (Residues: 241-326; Coverage: 26%)
Gene names: ELAVL1, HUR
Sequence domains: RNA recognition motif
AU-rich RNA Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 11 nucleotides
Theoretical weight: 3.37 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 151.287Å b: 40.258Å c: 106.496Å
α: 90° β: 132.95° γ: 90°
R-values:
R R work R free
0.202 0.201 0.231
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

17 review citations

Understanding and targeting the disease-related RNA binding protein human antigen R (HuR).
Schultz et al. (2020)
16 more

6 mentions without citation

A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus.
Simion et al. (2020)
5 more