› › Function and Biology

X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF15238
Domain description: Omega loop, TEAD interating region 3
Occurring in:
  1. Transcriptional coactivator YAP1
The deposited structure of PDB entry 6ge6 contains 1 copy of Pfam domain PF15238 (Omega loop, TEAD interating region 3) in Transcriptional coactivator YAP1. Showing 1 copy in chain B [auth L].

PF17725
Domain description: YAP binding domain
Occurring in:
  1. Transcriptional enhancer factor TEF-3
The deposited structure of PDB entry 6ge6 contains 1 copy of Pfam domain PF17725 (YAP binding domain) in Transcriptional enhancer factor TEF-3. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR041086
Domain description: YAP binding domain
Occurring in:
  1. Transcriptional enhancer factor TEF-3

Structure domains

CATH CATH domains
6.20.430.10
Class: Special
Architecture: Other non-globular
Topology: Virus Scaffolding Protein; Chain A
Homology: Virus Scaffolding Protein; Chain A
Occurring in:
  1. Transcriptional coactivator YAP1
The deposited structure of PDB entry 6ge6 contains 1 copy of CATH domain 6.20.430.10 (Virus Scaffolding Protein; Chain A) in Transcriptional coactivator YAP1. Showing 1 copy in chain B [auth L].
2.70.50.80
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Coagulation Factor XIII; Chain A, domain 1
Homology: Coagulation Factor XIII; Chain A, domain 1
Occurring in:
  1. Transcriptional enhancer factor TEF-3
The deposited structure of PDB entry 6ge6 contains 1 copy of CATH domain 2.70.50.80 (Coagulation Factor XIII; Chain A, domain 1) in Transcriptional enhancer factor TEF-3. Showing 1 copy in chain A.

Quick links