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p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: apoptotic process
Cellular component: nucleus

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00870
Domain description: P53 DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 6ggd contains 2 copies of Pfam domain PF00870 (P53 DNA-binding domain) in Cellular tumor antigen p53. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002117
Domain description: p53 tumour suppressor family
Occurring in:
  1. Cellular tumor antigen p53
IPR011615
Domain description: p53, DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53
IPR012346
Domain description: p53/RUNT-type transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53

Structure domain

CATH CATH domain
2.60.40.720
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 6ggd contains 2 copies of CATH domain 2.60.40.720 (Immunoglobulin-like) in Cellular tumor antigen p53. Showing 1 copy in chain B.

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