› 6ggh

X-ray diffraction
1.7Å resolution

Human jak1 kinase domain in complex with inhibitor

Released:
DOI: 10.2210/pdb6ggh/pdb
Model geometry
Fit model/data
PDB entry 6ggh coloured by chain, front view.
PDB entry 6ggh coloured by chain, side view.
PDB entry 6ggh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Read JA, Augustin M, Lammens A

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.72 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P23458 (Residues: 863-1154; Coverage: 25%)
Gene names: JAK1, JAK1A, JAK1B
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EYQ 2 x EYQ
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 42.987Å b: 170.327Å c: 45.026Å
α: 90° β: 94.06° γ: 90°
R-values:
R R work R free
0.192 0.189 0.262
Expression system: Not provided

Quick links