EC 3.4.24.11: Neprilysin
Reaction catalysed:
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
Alternative Name(s):
- Acute lymphoblastic leukemia antigen
- CALLA
- CALLA (common acute lymphoblastic leukemia-associated) antigens
- CALLA antigen
- CALLA glycoprotein
- CALLA glycoproteins
- CD10
- Common acute lymphoblastic leukemia antigen
- Common acute lymphoblastic leukemia-associated antigens
- Endopeptidase
- Endopeptidase 24.11
- Endopeptidase-2
- Enkephalinase
- Kidney-brush-border neutral endopeptidase
- Kidney-brush-border neutral peptidase
- Kidney-brush-border neutral proteinase
- Membrane metalloendopeptidase
- NEP
- Neutral endopeptidase
- Neutral endopeptidase 24.11
- Neutral metallendopeptidase
GO terms
Biochemical function:
Biological process:
- positive regulation of long-term synaptic potentiation
- amyloid-beta clearance by cellular catabolic process
- amyloid-beta clearance
- replicative senescence
- cellular response to UV-B
- cellular response to UV-A
- cellular response to cytokine stimulus
- neuropeptide processing
- positive regulation of neurogenesis
- amyloid-beta metabolic process
- creatinine metabolic process
- response to estrogen
- hormone catabolic process
- lung development
- protein catabolic process
- sensory perception of pain
- protein processing
- bradykinin catabolic process
- substance P catabolic process
- learning or memory
- peptide metabolic process
- proteolysis
- placenta development
- kidney development
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotationsStructure domains
CATH domains
3.40.390.10
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Collagenase (Catalytic Domain)
Homology:
Collagenase (Catalytic Domain)
Occurring in:
