› 6gih

X-ray diffraction
1.96Å resolution

Crystal Structure of CK2alpha with CAM187 bound

Released:
DOI: 10.2210/pdb6gih/pdb
PDB entry 6gih coloured by chain, front view.
PDB entry 6gih coloured by chain, side view.
PDB entry 6gih coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel non-ATP competitive small molecules targeting the CK2 α/β interface.
Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR
OpenAccess logo Bioorg Med Chem 26 3016-3020 (2018)
PMID: 29759799

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-549905 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 328 amino acids
Theoretical weight: 39.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68400 (Residues: 2-329; Coverage: 84%)
  • Best match: P68400-2 (Residues: 1-193)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ACT 2 x ACT
Ligand EZN 1 x EZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P21
Unit cell:
a: 59.488Å b: 45.117Å c: 62.889Å
α: 90° β: 111.23° γ: 90°
R-values:
R R work R free
0.182 0.18 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2.
Spinello et al. (2021)
2 more