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Crystal structure of anti-tau antibody dmCBTAU-27.1, double mutant (S31Y, T100I) of CBTAU-27.1, in complex with Tau peptide A8119B (residues 299-318)

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00418
Domain description: Tau and MAP protein, tubulin-binding repeat
Occurring in:
  1. Microtubule-associated protein tau
The deposited structure of PDB entry 6gk7 contains 1 copy of Pfam domain PF00418 (Tau and MAP protein, tubulin-binding repeat) in Microtubule-associated protein tau. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
  2. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
  2. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
  2. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
  2. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
  2. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
  2. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
  2. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I)
The deposited structure of PDB entry 6gk7 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I). Showing 2 copies in chain A [auth L].

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