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Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 2

Source organism: Schistosoma mansoni
Biochemical function: metal ion binding
Biological process: heterochromatin formation
Cellular component: nucleus

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EC 3.5.1.98: Histone deacetylase

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Systematic name:
Histone amidohydrolase
Alternative Name(s):
  • HDAC

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00850
Domain description: Histone deacetylase domain
Occurring in:
  1. histone deacetylase
The deposited structure of PDB entry 6gxa contains 4 copies of Pfam domain PF00850 (Histone deacetylase domain) in histone deacetylase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000286
Domain description: Histone deacetylase family
Occurring in:
  1. histone deacetylase
IPR023801
Domain description: Histone deacetylase domain
Occurring in:
  1. histone deacetylase
IPR037138
Domain description: Histone deacetylase domain superfamily
Occurring in:
  1. histone deacetylase
IPR023696
Domain description: Ureohydrolase domain superfamily
Occurring in:
  1. histone deacetylase

Structure domain

CATH CATH domain
3.40.800.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Arginase; Chain A
Homology: Histone deacetylase domain
Occurring in:
  1. histone deacetylase
The deposited structure of PDB entry 6gxa contains 4 copies of CATH domain 3.40.800.20 (Arginase; Chain A) in histone deacetylase. Showing 1 copy in chain B.

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