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The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster

Source organisms:
Biochemical function: DNA-directed DNA polymerase activity
Biological process: DNA repair
Cellular component: epsilon DNA polymerase complex

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EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF22634
Domain description: DNA polymerase epsilon catalytic subunit A, thumb domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A

PF03104
Domain description: DNA polymerase family B, exonuclease domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
The deposited structure of PDB entry 6h1v contains 1 copy of Pfam domain PF03104 (DNA polymerase family B, exonuclease domain) in DNA polymerase epsilon catalytic subunit A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR042087
Domain description: DNA polymerase family B, thumb domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR006134
Domain description: DNA-directed DNA polymerase, family B, multifunctional domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR023211
Domain description: DNA polymerase, palm domain superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR006172
Domain description: DNA-directed DNA polymerase, family B
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR006133
Domain description: DNA-directed DNA polymerase, family B, exonuclease domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR029703
Domain description: DNA polymerase epsilon catalytic subunit
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A

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