› 6h2l

X-ray diffraction
1.5Å resolution

Receptor-binding domain of Proteus mirabilis Uroepithelial Cell Adhesin UcaD21-217

Released:
DOI: 10.2210/pdb6h2l/pdb
PDB entry 6h2l coloured by chain, front view.
PDB entry 6h2l coloured by chain, side view.
PDB entry 6h2l coloured by chain, top view.
Source organism: Proteus mirabilis HI4320
Primary publication:
Structures of two fimbrial adhesins, AtfE and UcaD, from the uropathogen Proteus mirabilis.
Jiang W, Ubhayasekera W, Pearson MM, Knight SD
Acta Crystallogr D Struct Biol 74 1053-1062 (2018)
PMID: 30387764

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fimbrial-type adhesion domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 204 amino acids
Theoretical weight: 21.79 KDa
Source organism: Proteus mirabilis HI4320
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B4EV65 (Residues: 21-217; Coverage: 58%)
Gene name: PMI0533

Ligands and Environments

1 bound ligand:
Ligand SO4 9 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 30.473Å b: 49.828Å c: 61.833Å
α: 86.45° β: 74.51° γ: 75.52°
R-values:
R R work R free
0.215 0.214 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens.
Sarshar et al. (2020)
1 other article

1 mention without citation

Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli.
Hancock et al. (2022)