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Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and LeuPro ligand

Source organism: Homo sapiens
Biochemical function: proline dipeptidase activity
Biological process: negative regulation of programmed cell death
Cellular component: extracellular exosome

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EC 3.4.13.9: Xaa-Pro dipeptidase

Reaction catalysed:
Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.
Systematic name:
-
Alternative Name(s):
  • Gamma-peptidase
  • Imidodipeptidase
  • Peptidase D
  • Prolidase
  • Proline dipeptidase
  • X-Pro dipeptidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00557
Domain description: Metallopeptidase family M24
Occurring in:
  1. Xaa-Pro dipeptidase
The deposited structure of PDB entry 6h2q contains 2 copies of Pfam domain PF00557 (Metallopeptidase family M24) in Xaa-Pro dipeptidase. Showing 1 copy in chain A.

PF05195
Domain description: Aminopeptidase P, N-terminal domain
Occurring in:
  1. Xaa-Pro dipeptidase
The deposited structure of PDB entry 6h2q contains 2 copies of Pfam domain PF05195 (Aminopeptidase P, N-terminal domain) in Xaa-Pro dipeptidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036005
Domain description: Creatinase/aminopeptidase-like
Occurring in:
  1. Xaa-Pro dipeptidase
IPR007865
Domain description: Aminopeptidase P, N-terminal
Occurring in:
  1. Xaa-Pro dipeptidase
IPR029149
Domain description: Creatinase/Aminopeptidase P/Spt16, N-terminal
Occurring in:
  1. Xaa-Pro dipeptidase
IPR001131
Domain description: Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
Occurring in:
  1. Xaa-Pro dipeptidase
IPR000994
Domain description: Peptidase M24
Occurring in:
  1. Xaa-Pro dipeptidase

Structure domains

CATH CATH domains
3.90.230.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Creatine Amidinohydrolase
Homology: Creatinase/methionine aminopeptidase superfamily
Occurring in:
  1. Xaa-Pro dipeptidase
The deposited structure of PDB entry 6h2q contains 2 copies of CATH domain 3.90.230.10 (Creatine Amidinohydrolase) in Xaa-Pro dipeptidase. Showing 1 copy in chain A.
3.40.350.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Creatine Amidinohydrolase; Chain A, domain 1
Homology: Creatinase/prolidase N-terminal domain
Occurring in:
  1. Xaa-Pro dipeptidase
The deposited structure of PDB entry 6h2q contains 2 copies of CATH domain 3.40.350.10 (Creatine Amidinohydrolase; Chain A, domain 1) in Xaa-Pro dipeptidase. Showing 1 copy in chain A.

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