6h6a

X-ray diffraction
2Å resolution

Crystal structure of UNC119 in complex with LCK peptide

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138956 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Protein unc-119 homolog A Chain: D
Molecule details ›
Chain: D
Length: 182 amino acids
Theoretical weight: 21.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13432 (Residues: 59-240; Coverage: 76%)
Gene names: RG4, UNC119
Sequence domains: GMP-PDE, delta subunit
Structure domains: GMP phosphodiesterase, delta subunit
Tyrosine-protein kinase Lck Chains: E, H, K
Molecule details ›
Chains: E, H, K
Length: 10 amino acids
Theoretical weight: 992 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06239 (Residues: 2-11; Coverage: 2%)
Gene name: LCK
Protein unc-119 homolog A Chains: G, J
Molecule details ›
Chains: G, J
Length: 182 amino acids
Theoretical weight: 21.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13432 (Residues: 59-240; Coverage: 76%)
Gene names: RG4, UNC119
Sequence domains: GMP-PDE, delta subunit
Structure domains: GMP phosphodiesterase, delta subunit

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 50.09Å b: 63.62Å c: 188.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.171 0.212
Expression systems:
  • Escherichia coli
  • Not provided