› 6hg9

X-ray diffraction
3.62Å resolution

Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II

Released:
DOI: 10.2210/pdb6hg9/pdb
PDB entry 6hg9 coloured by chain, front view.
PDB entry 6hg9 coloured by chain, side view.
PDB entry 6hg9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Goepfert A, Lehmann S, Blank J, Kolbinger F, Rondeau JM
Immunity 52 499-512.e5 (2020)
PMID: 32187518

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185451 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-17F Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96PD4 (Residues: 31-163; Coverage: 100%)
Gene name: IL17F
Sequence domains: Interleukin-17
Interleukin-17 receptor C Chain: B
Molecule details ›
Chain: B
Length: 451 amino acids
Theoretical weight: 50.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NAC3 (Residues: 95-538; Coverage: 58%)
  • Best match: Q8NAC3-2 (Residues: 21-467)
Gene names: IL17RC, UNQ6118/PRO20040/PRO38901
Sequence domains: Interleukin-17 receptor extracellular region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R32
Unit cell:
a: 160.312Å b: 160.312Å c: 197.983Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.226 0.258
Expression system: Homo sapiens

Quick links

Citations

19 review citations

The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside.
Liu et al. (2020)
18 more

3 mentions without citation

Topology evaluation of models for difficult targets in the 14th round of the critical assessment of protein structure prediction (CASP14).
Kinch et al. (2021)
2 more