6hhc

X-ray diffraction
2.7Å resolution

Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-208969 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
FXIA ANTIBODY FAB LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
FXIA ANTIBODY FAB HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 23.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Coagulation factor XIa light chain Chain: A

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Unit cell:
a: 61.941Å b: 70.679Å c: 185.893Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.227 0.314
Expression system: Homo sapiens