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Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.

Ramrath DJF, Niemann M, Leibundgut M, Bieri P, Prange C, Horn EK, Leitner A, Boehringer D, Schneider A, Ban N
Science 362 (2018)
Related entries: 6hiv, 6hiw, 6hix, 6hiz

Cited: 71 times
EuropePMC logo PMID: 30213880

Abstract

Ribosomal RNA (rRNA) plays key functional and architectural roles in ribosomes. Using electron microscopy, we determined the atomic structure of a highly divergent ribosome found in mitochondria of Trypanosoma brucei, a unicellular parasite that causes sleeping sickness in humans. The trypanosomal mitoribosome features the smallest rRNAs and contains more proteins than all known ribosomes. The structure shows how the proteins have taken over the role of architectural scaffold from the rRNA: They form an autonomous outer shell that surrounds the entire particle and stabilizes and positions the functionally important regions of the rRNA. Our results also reveal the "minimal" set of conserved rRNA and protein components shared by all ribosomes that help us define the most essential functional elements.

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  1. Biological and Genomic Characterization of a Novel Jumbo Bacteriophage, vB_VhaM_pir03 with Broad Host Lytic Activity against Vibrio harveyi. Misol GN, Kokkari C, Katharios P. Pathogens 9 E1051 (2020)
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Reviews citing this publication (17)

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  3. 8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification. Hahm JY, Park J, Jang ES, Chi SW. Exp Mol Med 54 1626-1642 (2022)
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  6. The World of Stable Ribonucleoproteins and Its Mapping With Grad-Seq and Related Approaches. Gerovac M, Vogel J, Smirnov A. Front Mol Biosci 8 661448 (2021)
  7. An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight. Tomal A, Kwasniak-Owczarek M, Janska H. Cells 8 E1562 (2019)
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  10. A Comparative Perspective on Ribosome Biogenesis: Unity and Diversity Across the Tree of Life. Jüttner M, Ferreira-Cerca S. Methods Mol Biol 2533 3-22 (2022)
  11. Divergent Mitochondrial Ribosomes in Unicellular Parasitic Protozoans. Dass S, Mather MW, Ke H. Trends Parasitol 36 318-321 (2020)
  12. Mitochondrial RNA quality control in trypanosomes. Aphasizheva I, Aphasizhev R. Wiley Interdiscip Rev RNA 12 e1638 (2021)
  13. Types and Functions of Mitoribosome-Specific Ribosomal Proteins across Eukaryotes. Scaltsoyiannes V, Corre N, Waltz F, Giegé P. Int J Mol Sci 23 3474 (2022)
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  15. Separating the Wheat from the Chaff: RNA Editing and Selection of Translatable mRNA in Trypanosome Mitochondria. Maslov DA. Pathogens 8 E105 (2019)
  16. Ribosome Specialization in Protozoa Parasites. Rodríguez-Almonacid CC, Kellogg MK, Karamyshev AL, Karamysheva ZN. Int J Mol Sci 24 7484 (2023)
  17. The Beak of Eukaryotic Ribosomes: Life, Work and Miracles. Martín-Villanueva S, Galmozzi CV, Ruger-Herreros C, Kressler D, de la Cruz J. Biomolecules 14 882 (2024)

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