› 6hkx

X-ray diffraction
2.8Å resolution

Eg5-inhibitor complex

Released:
DOI: 10.2210/pdb6hkx/pdb
Model geometry
Fit model/data
PDB entry 6hkx coloured by chain, front view.
PDB entry 6hkx coloured by chain, side view.
PDB entry 6hkx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
Indorato RL, Talapatra SK, Lin F, Haider S, Mackay SP, Kozielski F, Skoufias DA
Mol Cancer Ther 18 2394-2406 (2019)
PMID: 31488701

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 368 amino acids
Theoretical weight: 41.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52732 (Residues: 1-368; Coverage: 35%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain

Ligands and Environments

4 bound ligands:
Ligand ADP 2 x ADP
Ligand GCE 2 x GCE
Ligand MG 2 x MG
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 68.91Å b: 80.13Å c: 135.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.179 0.271
Expression system: Escherichia coli

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Citations

1 review citation

Antibody-drug conjugates: Recent advances in payloads.
Wang et al. (2023)
3 other articles