› 6hou

X-ray diffraction
1.8Å resolution

Human protein kinase CK2 alpha in complex with vanillin

Released:
DOI: 10.2210/pdb6hou/pdb
PDB entry 6hou coloured by chain, front view.
PDB entry 6hou coloured by chain, side view.
PDB entry 6hou coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin.
Cozza G, Zonta F, Dalle Vedove A, Venerando A, Dall'Acqua S, Battistutta R, Ruzzene M, Lolli G
FEBS J 287 1850-1864 (2020)
PMID: 31661600

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-549905 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 336 amino acids
Theoretical weight: 40.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-336; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand V55 1 x V55
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21
Unit cell:
a: 58.225Å b: 46.543Å c: 63.411Å
α: 90° β: 111.74° γ: 90°
R-values:
R R work R free
0.174 0.172 0.208
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Effects of Bacterial Nanocellulose Loaded with Curcumin and Its Degradation Products on Human Dermal Fibroblasts.
Zikmundova et al. (2020)
1 more

3 mentions without citation

Qualitative Estimation of Protein-Ligand Complex Stability through Thermal Titration Molecular Dynamics Simulations.
Pavan et al. (2022)
2 more