6hug

Electron Microscopy
3.1Å resolution

CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38.

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-209358 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (8 distinct):
Gamma-aminobutyric acid receptor subunit alpha-1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 437 amino acids
Theoretical weight: 49.85 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
Gene name: GABRA1
Gamma-aminobutyric acid receptor subunit beta-3 Chains: B, E
Molecule details ›
Chains: B, E
Length: 473 amino acids
Theoretical weight: 54.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Gene name: GABRB3
Gamma-aminobutyric acid receptor subunit gamma-2 Chain: C
Megabody Mb38 Chain: G

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.1Å
Relevant EMDB volumes: EMD-0275
Expression systems:
  • Homo sapiens
  • Escherichia coli