PDB 6hug structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

extracellular ligand-gated monoatomic ion channel activity

Biological process:

monoatomic ion transmembrane transport

Cellular component:

membrane

Sequence domains:

13 more domains

Structure analysis Details

Assembly composition:

hetero hexamer (preferred)

PDBe Complex ID:

PDB-CPX-209358 (preferred)

Entry contents:

4 distinct polypeptide molecules

Macromolecules (8 distinct):

Gamma-aminobutyric acid receptor subunit alpha-1 Chains: A, D

Molecule details ›

Chains: A, D
Length: 437 amino acids
Theoretical weight: 49.85 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:

Canonical: P08219 (Residues: 28-456; Coverage: 100%)

Gene name: GABRA1
Sequence domains:

Gamma-aminobutyric acid receptor subunit beta-3 Chains: B, E

Molecule details ›

Chains: B, E
Length: 473 amino acids
Theoretical weight: 54.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P28472 (Residues: 26-473; Coverage: 100%)
Best match: P28472-2 (Residues: 1-473)

Gene name: GABRB3
Sequence domains:

Gamma-aminobutyric acid receptor subunit gamma-2 Chain: C

Molecule details ›

Chain: C
Length: 495 amino acids
Theoretical weight: 56.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P18507 (Residues: 1-475; Coverage: 100%)

Gene name: GABRG2
Sequence domains:

Megabody Mb38 Chain: G

Molecule details ›

Chain: G
Length: 539 amino acids
Theoretical weight: 57.78 KDa
Source organism: Lama glama
Expression system: Escherichia coli