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CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38.

Source organisms:
Biochemical function: extracellular ligand-gated monoatomic ion channel activity
Biological process: monoatomic ion transmembrane transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02932
Domain description: Neurotransmitter-gated ion-channel transmembrane region
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
The deposited structure of PDB entry 6huk contains 2 copies of Pfam domain PF02932 (Neurotransmitter-gated ion-channel transmembrane region) in Gamma-aminobutyric acid receptor subunit alpha-1. Showing 1 copy in chain A.
The deposited structure of PDB entry 6huk contains 2 copies of Pfam domain PF02932 (Neurotransmitter-gated ion-channel transmembrane region) in Gamma-aminobutyric acid receptor subunit beta-3. Showing 1 copy in chain B.
The deposited structure of PDB entry 6huk contains 1 copy of Pfam domain PF02932 (Neurotransmitter-gated ion-channel transmembrane region) in Gamma-aminobutyric acid receptor subunit gamma-2. Showing 1 copy in chain C.

PF02931
Domain description: Neurotransmitter-gated ion-channel ligand binding domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
The deposited structure of PDB entry 6huk contains 2 copies of Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) in Gamma-aminobutyric acid receptor subunit alpha-1. Showing 1 copy in chain A.
The deposited structure of PDB entry 6huk contains 2 copies of Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) in Gamma-aminobutyric acid receptor subunit beta-3. Showing 1 copy in chain B.
The deposited structure of PDB entry 6huk contains 1 copy of Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) in Gamma-aminobutyric acid receptor subunit gamma-2. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR006201
Domain description: Neurotransmitter-gated ion-channel
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR006028
Domain description: Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR001390
Domain description: Gamma-aminobutyric-acid A receptor, alpha subunit
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
IPR036734
Domain description: Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR002289
Domain description: Gamma-aminobutyric-acid A receptor, beta subunit
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit beta-3
IPR005431
Domain description: Gamma-aminobutyric-acid A receptor, alpha 1 subunit
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
IPR005437
Domain description: Gamma-aminobutyric acid receptor subunit gamma-1/4
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
IPR006029
Domain description: Neurotransmitter-gated ion-channel transmembrane domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR036719
Domain description: Neurotransmitter-gated ion-channel transmembrane domain superfamily
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR038050
Domain description: Neuronal acetylcholine receptor
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR018000
Domain description: Neurotransmitter-gated ion-channel, conserved site
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR006202
Domain description: Neurotransmitter-gated ion-channel ligand-binding domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
  2. Gamma-aminobutyric acid receptor subunit beta-3
  3. Gamma-aminobutyric acid receptor subunit gamma-2
IPR005439
Domain description: Gamma-aminobutyric-acid A receptor, gamma 2 subunit
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Megabody Mb38
IPR040838
Domain description: SabA, N-terminal extracellular adhesion domain
Occurring in:
  1. Megabody Mb38
IPR047024
Domain description: Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
IPR047079
Domain description: Gamma-aminobutyric acid receptor subunit alpha-1, extracellular domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit alpha-1
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Megabody Mb38
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Megabody Mb38
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Megabody Mb38
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Megabody Mb38

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