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Crystal structure of CdaA from Bacillus subtilis

Source organism: Bacillus subtilis
Biochemical function: adenylate cyclase activity
Biological process: cAMP biosynthetic process
Cellular component: not assigned

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EC 2.7.7.85: Diadenylate cyclase

Reaction catalysed:
2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate
Systematic name:
ATP:ATP adenylyltransferase (cyclizing)
Alternative Name(s):
  • Cyclic-di-AMP synthase
  • DacA (gene name)
  • DisA (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02457
Domain description: DisA bacterial checkpoint controller nucleotide-binding
Occurring in:
  1. Cyclic di-AMP synthase CdaA
The deposited structure of PDB entry 6huw contains 2 copies of Pfam domain PF02457 (DisA bacterial checkpoint controller nucleotide-binding) in Cyclic di-AMP synthase CdaA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036888
Domain description: DNA integrity scanning protein, DisA, N-terminal domain superfamily
Occurring in:
  1. Cyclic di-AMP synthase CdaA
IPR003390
Domain description: DNA integrity scanning protein, DisA, N-terminal
Occurring in:
  1. Cyclic di-AMP synthase CdaA
IPR034701
Domain description: Diadenylate cyclase CdaA
Occurring in:
  1. Cyclic di-AMP synthase CdaA
IPR014046
Domain description: Diadenylate cyclase
Occurring in:
  1. Cyclic di-AMP synthase CdaA

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