› 6hvk

Solution NMR

Pepducin UT-Pep2 a biased allosteric agonist of Urotensin-II receptor

Released:
DOI: 10.2210/pdb6hvk/pdb
PDB entry 6hvk coloured by chain, ensemble of 10 models, front view.
PDB entry 6hvk coloured by chain, ensemble of 10 models, side view.
PDB entry 6hvk coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands.
Nassour H, Hoang TA, Martin RD, Dallagnol JCC, Billard É, Létourneau M, Novellino E, Carotenuto A, Allen BG, Tanny JC, Fournier A, Hébert TE, Chatenet D
OpenAccess logo J Biol Chem 297 101057 (2021)
PMID: 34389356

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193858 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urotensin-2 receptor Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UKP6 (Residues: 153-166; Coverage: 4%)
Gene names: GPR14, UTS2R

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System.
Xu et al. (2022)

1 mention without citation

Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands.
Nassour et al. (2021)