› 6hx4

X-ray diffraction
2.95Å resolution

Fab fragment of a native monomer-selective antibody in complex with alpha-1-antitrypsin

Released:
DOI: 10.2210/pdb6hx4/pdb
PDB entry 6hx4 coloured by chain, front view.
PDB entry 6hx4 coloured by chain, side view.
PDB entry 6hx4 coloured by chain, top view.
Source organisms:
Entry authors: Elliston ELK, Miranda E, Perez J, Jagger AM, Lomas DA, Irving JA

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208321 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Alpha-1-antitrypsin Chains: A, B
Molecule details ›
Chains: A, B
Length: 397 amino acids
Theoretical weight: 44.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P01009 (Residues: 24-418; Coverage: 100%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Fab 1D9 heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 228 amino acids
Theoretical weight: 24.38 KDa
Source organism: Mus musculus
Fab 1D9 light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 217 amino acids
Theoretical weight: 23.86 KDa
Source organism: Mus musculus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: C2
Unit cell:
a: 247.48Å b: 36.75Å c: 201.78Å
α: 90° β: 126.07° γ: 90°
R-values:
R R work R free
0.234 0.231 0.277
Expression system: Escherichia coli K-12

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