› 6hyn

X-ray diffraction
1.14Å resolution

Structure of ATG13 LIR motif bound to GABARAP

Released:
DOI: 10.2210/pdb6hyn/pdb
PDB entry 6hyn coloured by chain, front view.
PDB entry 6hyn coloured by chain, side view.
PDB entry 6hyn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Wirth M, Zhang W, Razi M, Nyoni L, Joshi D, O'Reilly N, Johansen T, Tooze SA, Mouilleron S
OpenAccess logo Nat Commun 10 2055 (2019)
PMID: 31053714

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130843 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Autophagy-related protein 13; Gamma-aminobutyric acid receptor-associated protein Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 16.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75143 (Residues: 441-454; Coverage: 3%)
  • Canonical: O95166 (Residues: 1-117; Coverage: 100%)
Gene names: ATG13, FLC3B, GABARAP, HT004, KIAA0652
Sequence domains: Autophagy protein Atg8 ubiquitin like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: I23
Unit cell:
a: 101.131Å b: 101.131Å c: 101.131Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.185
Expression system: Escherichia coli

Quick links

Citations

13 review citations

The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson's Disease.
Lin et al. (2019)
12 more

1 mention without citation

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Wirth et al. (2019)