6i2k

Electron Microscopy
3.4Å resolution

Structure of EV71 complexed with its receptor SCARB2

Released:
Source organisms:
Related structures: EMD-0332

Function and Biology Details

Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
PDBe Complex ID:
PDB-CPX-171910 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (10 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 32.76 KDa
Source organism: Enterovirus A71
UniProt:
  • Canonical: Q66479 (Residues: 566-862; Coverage: 14%)
Sequence domains: Picornavirus coat protein
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 254 amino acids
Theoretical weight: 27.78 KDa
Source organism: Enterovirus A71
UniProt:
  • Canonical: Q66479 (Residues: 70-323; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: C
Capsid protein VP4 Chain: D
Lysosome membrane protein 2 Chain: E

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0332
Expression system: Homo sapiens