Function and Biology Details
Reaction catalysed:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Renin and Angiotensin-1 (preferred)
PDBe Complex ID:
PDB-CPX-133567 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Angiotensinogen
Molecule details ›
Chain: A
Length: 458 amino acids
Theoretical weight: 50.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Serpin (serine protease inhibitor)
Length: 458 amino acids
Theoretical weight: 50.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P01019 (Residues: 25-476; Coverage: 100%)
Sequence domains: Serpin (serine protease inhibitor)
Renin
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases
Length: 340 amino acids
Theoretical weight: 37.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I04-1
Spacegroup:
P6322
Expression system: Homo sapiens
