› 6i3y

X-ray diffraction
2.98Å resolution

Crystal structure of the human mitochondrial PRELID1K58V-TRIAP1 complex with PS

Released:
DOI: 10.2210/pdb6i3y/pdb
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PDB entry 6i3y coloured by chain, front view.
PDB entry 6i3y coloured by chain, side view.
PDB entry 6i3y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
Miliara X, Tatsuta T, Berry JL, Rouse SL, Solak K, Chorev DS, Wu D, Robinson CV, Matthews S, Langer T
OpenAccess logo Nat Commun 10 1130 (2019)
PMID: 30850607

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129078 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PRELI domain-containing protein 1, mitochondrial Chains: C, F
Molecule details ›
Chains: C, F
Length: 185 amino acids
Theoretical weight: 21.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y255 (Residues: 1-173; Coverage: 79%)
Gene names: CGI-106, PRELI, PRELID1, SBBI12
Sequence domains: PRELI-like family
TP53-regulated inhibitor of apoptosis 1 Chains: A, H
Molecule details ›
Chains: A, H
Length: 90 amino acids
Theoretical weight: 10.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43715 (Residues: 1-76; Coverage: 100%)
Gene names: 15E1.1, HSPC132, TRIAP1
Sequence domains: Uncharacterised protein family (UPF0203)

Ligands and Environments

2 bound ligands:
Ligand LMT 1 x LMT
Ligand P5S 2 x P5S
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6322
Unit cell:
a: 126Å b: 126Å c: 178.32Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.244 0.299
Expression system: Escherichia coli

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Citations

10 review citations

Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction.
Monzel et al. (2023)
9 more

1 mention without citation

The PTPIP51 TPR-Domain: A Novel Lipid Transfer Domain?
Giordano et al. (2021)

PDB-REDO

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