› 6i64

X-ray diffraction
1.91Å resolution

Crystal structure of human ERRg LBD in complex with bisphenol-E

Released:
DOI: 10.2210/pdb6i64/pdb
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PDB entry 6i64 coloured by chain, front view.
PDB entry 6i64 coloured by chain, side view.
PDB entry 6i64 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors.
Thouennon E, Delfosse V, Bailly R, Blanc P, Boulahtouf A, Grimaldi M, Barducci A, Bourguet W, Balaguer P
Cell Mol Life Sci 76 4769-4781 (2019)
PMID: 31127318

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158634 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62508 (Residues: 222-458; Coverage: 52%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

2 bound ligands:
Ligand H48 1 x H48
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P41212
Unit cell:
a: 64.32Å b: 64.32Å c: 138.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.237
Expression system: Escherichia coli

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Citations

1 review citation

Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis.
Tang et al. (2021)
2 other articles

1 mention without citation

Discovery of New Protein Targets of BPA Analogs and Derivatives Associated with Noncommunicable Diseases: A Virtual High-Throughput Screening.
Montes-Grajales et al. (2021)

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