› 6igm

Electron Microscopy
4Å resolution

Cryo-EM Structure of Human SRCAP Complex

Released:
DOI: 10.2210/pdb6igm/pdb
PDB entry 6igm coloured by chain, front view.
PDB entry 6igm coloured by chain, side view.
PDB entry 6igm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human SRCAP complex.
Feng Y, Tian Y, Wu Z, Xu Y
Cell Res 28 1121-1123 (2018)
PMID: 30337683
Related structures: EMD-9668

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166888 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
RuvB-like 1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 456 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: mammal environmental sample
UniProt:
  • Canonical: Q9Y265 (Residues: 1-456; Coverage: 100%)
Gene names: INO80H, NMP238, RUVBL1, TIP49, TIP49A
Sequence domains:
RuvB-like 2 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 463 amino acids
Theoretical weight: 51.22 KDa
Source organism: Homo sapiens
Expression system: mammal environmental sample
UniProt:
  • Canonical: Q9Y230 (Residues: 1-463; Coverage: 100%)
Gene names: CGI-46, INO80J, RUVBL2, TIP48, TIP49B
Sequence domains:
Actin-related protein 6 Chain: G
Molecule details ›
Chain: G
Length: 396 amino acids
Theoretical weight: 45.86 KDa
Source organism: Homo sapiens
Expression system: mammal environmental sample
UniProt:
  • Canonical: Q9GZN1 (Residues: 1-396; Coverage: 100%)
Gene names: ACTR6, CDA12
Sequence domains: Actin
Helicase SRCAP Chain: H
Molecule details ›
Chain: H
Length: 3230 amino acids
Theoretical weight: 343.92 KDa
Source organism: Homo sapiens
Expression system: mammal environmental sample
UniProt:
  • Canonical: Q6ZRS2 (Residues: 1-3230; Coverage: 100%)
Gene names: KIAA0309, SRCAP
Sequence domains:
unknown subunit Chain: X
Molecule details ›
Chain: X
Length: 62 amino acids
Theoretical weight: 5.29 KDa
Source organism: Homo sapiens
Expression system: mammal environmental sample

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-9668
Expression system: mammal environmental sample

Quick links

Citations

3 review citations

RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes.
Rodríguez et al. (2020)
2 more

4 mentions without citation

INO80 and SWR1 complexes: the non-identical twins of chromatin remodelling.
Willhoft et al. (2020)
3 more