› 6il3

X-ray diffraction
2.5Å resolution

Crystal structure of the FLT3 kinase bound to a small molecule inhibitor

Released:
DOI: 10.2210/pdb6il3/pdb
PDB entry 6il3 coloured by chain, front view.
PDB entry 6il3 coloured by chain, side view.
PDB entry 6il3 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Thomas CJ

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153242 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein kinase FLT3 Chain: A
Molecule details ›
Chain: A
Length: 370 amino acids
Theoretical weight: 43.04 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: P36888 (Residues: 564-958; Coverage: 36%)
Gene names: CD135, FLK2, FLT3, STK1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand A9R 1 x A9R
Ligand PO4 4 x PO4
Ligand CXS 2 x CXS
Ligand GOL 10 x GOL
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P43212
Unit cell:
a: 81.641Å b: 81.641Å c: 147.843Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.219
Expression system: Baculovirus expression vector pFastBac1-HM

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