Function and Biology Details
Reactions catalysed:
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)
N(6)-methyladenine in DNA + 2-oxoglutarate + O(2) = adenine in DNA + formaldehyde + succinate + CO(2)
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Nucleic acid dioxygenase ALKBH1 (preferred)
PDBe Complex ID:
PDB-CPX-533673 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleic acid dioxygenase ALKBH1
Molecule details ›
Chains: A, B, C
Length: 335 amino acids
Theoretical weight: 37.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: 2OG-Fe(II) oxygenase superfamily
Length: 335 amino acids
Theoretical weight: 37.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P0CB42 (Residues: 37-369; Coverage: 86%)
Sequence domains: 2OG-Fe(II) oxygenase superfamily
