› 6ion

X-ray diffraction
2.75Å resolution

The complex of C4.4A with its antibody 11H10 Fab fragment

Released:
DOI: 10.2210/pdb6ion/pdb
PDB entry 6ion coloured by chain, front view.
PDB entry 6ion coloured by chain, side view.
PDB entry 6ion coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/alpha-neurotoxin Domain
Jiang YB, Lin L, Chen S, Jiang LG, Kriegbaum MC, Gardsvoll H, Hansen LV, Li J, Ploug M, Yuan C, Huang MD
Int J Biol Sci 16 981-993 (2020)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208184 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
anti-C4.4A antibody 11H10, light chain Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.68 KDa
Source organism: Mus musculus
anti-C4.4A antibody 11H10, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.86 KDa
Source organism: Mus musculus
Ly6/PLAUR domain-containing protein 3 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 21.14 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: O95274 (Residues: 31-231; Coverage: 64%)
Gene names: C4.4A, LYPD3, UNQ491/PRO1007
Sequence domains: u-PAR/Ly-6 domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 51.86Å b: 63.96Å c: 107.71Å
α: 90° β: 96.1° γ: 90°
R-values:
R R work R free
0.2 0.197 0.254
Expression system: Drosophila melanogaster

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