GO terms
Biochemical function:
Biological process:
- negative regulation of IRE1-mediated unfolded protein response
- regulation of chromatin organization
- negative regulation of RNA export from nucleus
- positive regulation of transcription by RNA polymerase II
- heterochromatin formation
- response to heat
- sister chromatid cohesion
- termination of RNA polymerase II transcription
- termination of RNA polymerase I transcription
- regulation of DNA-templated transcription
- DNA-templated transcription elongation
- chromatin remodeling
- chromatin organization
- regulation of transcriptional start site selection at RNA polymerase II promoter
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 6iro contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.2. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_2_A_Pfam_PF00125_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of Pfam domain <span class='highlight'>PF00125 (Core histone H2A/H2B/H3/H4)</span> in <span class='highlight'>Histone H3.2</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 6iro contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1. Showing 1 copy in chain D [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_4_C_Pfam_PF00125_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of Pfam domain <span class='highlight'>PF00125 (Core histone H2A/H2B/H3/H4)</span> in <span class='highlight'>Histone H2A type 1</span>. Showing 1 copy in chain <span class='highlight'>D [auth C]</span>.")
![The deposited structure of PDB entry 6iro contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B 1.1. Showing 1 copy in chain E [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_5_D_Pfam_PF00125_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of Pfam domain <span class='highlight'>PF00125 (Core histone H2A/H2B/H3/H4)</span> in <span class='highlight'>Histone H2B 1.1</span>. Showing 1 copy in chain <span class='highlight'>E [auth D]</span>.")
![The deposited structure of PDB entry 6iro contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1. Showing 1 copy in chain D [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_4_C_Pfam_PF16211_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of Pfam domain <span class='highlight'>PF16211 (C-terminus of histone H2A)</span> in <span class='highlight'>Histone H2A type 1</span>. Showing 1 copy in chain <span class='highlight'>D [auth C]</span>.")
![The deposited structure of PDB entry 6iro contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_3_B_Pfam_PF15511_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of Pfam domain <span class='highlight'>PF15511 (Centromere kinetochore component CENP-T histone fold)</span> in <span class='highlight'>Histone H4</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 6iro contains 1 copy of Pfam domain PF09111 (SLIDE) in ISWI chromatin-remodeling complex ATPase ISW1. Showing 1 copy in chain A [auth L] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/6iro_1_L_Pfam_PF09111_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 1 copy of Pfam domain <span class='highlight'>PF09111 (SLIDE)</span> in <span class='highlight'>ISWI chromatin-remodeling complex ATPase ISW1</span>. Showing 1 copy in chain <span class='highlight'>A [auth L]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 6iro contains 1 copy of Pfam domain PF09110 (HAND) in ISWI chromatin-remodeling complex ATPase ISW1. Showing 1 copy in chain A [auth L] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/6iro_1_L_Pfam_PF09110_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 1 copy of Pfam domain <span class='highlight'>PF09110 (HAND)</span> in <span class='highlight'>ISWI chromatin-remodeling complex ATPase ISW1</span>. Showing 1 copy in chain <span class='highlight'>A [auth L]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 6iro contains 1 copy of Pfam domain PF00271 (Helicase conserved C-terminal domain) in ISWI chromatin-remodeling complex ATPase ISW1. Showing 1 copy in chain A [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_1_L_Pfam_PF00271_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 1 copy of Pfam domain <span class='highlight'>PF00271 (Helicase conserved C-terminal domain)</span> in <span class='highlight'>ISWI chromatin-remodeling complex ATPase ISW1</span>. Showing 1 copy in chain <span class='highlight'>A [auth L]</span>.")
![The deposited structure of PDB entry 6iro contains 1 copy of Pfam domain PF00176 (SNF2-related domain) in ISWI chromatin-remodeling complex ATPase ISW1. Showing 1 copy in chain A [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_1_L_Pfam_PF00176_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 1 copy of Pfam domain <span class='highlight'>PF00176 (SNF2-related domain)</span> in <span class='highlight'>ISWI chromatin-remodeling complex ATPase ISW1</span>. Showing 1 copy in chain <span class='highlight'>A [auth L]</span>.")
InterPro annotations
IPR004823
Domain description:
TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
Occurring in:
CATH domain![The deposited structure of PDB entry 6iro contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H3.2. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_2_A_CATH_1.10.20.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of CATH domain <span class='highlight'>1.10.20.10 (Histone, subunit A)</span> in <span class='highlight'>Histone H3.2</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 6iro contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H4. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_3_B_CATH_1.10.20.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of CATH domain <span class='highlight'>1.10.20.10 (Histone, subunit A)</span> in <span class='highlight'>Histone H4</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 6iro contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H2A type 1. Showing 1 copy in chain D [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_4_C_CATH_1.10.20.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of CATH domain <span class='highlight'>1.10.20.10 (Histone, subunit A)</span> in <span class='highlight'>Histone H2A type 1</span>. Showing 1 copy in chain <span class='highlight'>D [auth C]</span>.")
![The deposited structure of PDB entry 6iro contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H2B 1.1. Showing 1 copy in chain E [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/6iro_5_D_CATH_1.10.20.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6iro</span> contains 2 copies of CATH domain <span class='highlight'>1.10.20.10 (Histone, subunit A)</span> in <span class='highlight'>Histone H2B 1.1</span>. Showing 1 copy in chain <span class='highlight'>E [auth D]</span>.")