› 6itt

X-ray diffraction
2.1Å resolution

Crystal structure of unactivated c-KIT in complex with compound

Released:
DOI: 10.2210/pdb6itt/pdb
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PDB entry 6itt coloured by chain, front view.
PDB entry 6itt coloured by chain, side view.
PDB entry 6itt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wu TS, Wu SY

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 37.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10721 (Residues: 547-693, 754-935; Coverage: 35%)
  • Best match: P10721-4 (Residues: 27-32, 35-216)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand AWO 2 x AWO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 62.629Å b: 63.087Å c: 196.812Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.235
Expression system: Spodoptera frugiperda

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