Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase A22A, presenilin
- Peptidase A22A, presenilin 1
- Amyloidogenic glycoprotein, amyloid-beta peptide
- Amyloidogenic glycoprotein
- Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
- Gamma-secretase subunit Aph-1
- Amyloidogenic glycoprotein, intracellular domain, conserved site
- PH-like domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
Amyloid-beta protein 40/42 complex (preferred)
PDBe Complex ID:
PDB-CPX-138362 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (7 distinct):
Nicastrin
Molecule details ›
Chain: A
Length: 709 amino acids
Theoretical weight: 78.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 709 amino acids
Theoretical weight: 78.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q92542 (Residues: 1-709; Coverage: 100%)
Sequence domains:
Presenilin-1
Molecule details ›
Chain: B
Length: 467 amino acids
Theoretical weight: 52.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Presenilin
Length: 467 amino acids
Theoretical weight: 52.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P49768 (Residues: 1-467; Coverage: 100%)
Sequence domains: Presenilin
Gamma-secretase subunit APH-1A
Gamma-secretase subunit PEN-2
C83
