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Capsid Structure of a Freshwater Cyanophage Siphoviridae Mic1.

Jin H, Jiang YL, Yang F, Zhang JT, Li WF, Zhou K, Ju J, Chen Y, Zhou CZ
Structure 27 1508-1516.e3 (2019)
Cited: 14 times
EuropePMC logo PMID: 31378451

Abstract

Cyanobacteria are the most abundant photosynthetic microorganisms, the global distribution of which is mainly regulated by the corresponding cyanophages. A systematic screening of water samples in the Lake Chaohu enabled us to isolate a freshwater siphocyanophage that infects Microcystis wesenbergii, thus termed Mic1. Using cryoelectron microscopy, we solved the 3.5-Å structure of Mic1 capsid. The major capsid protein gp40 of an HK97-like fold forms two types of capsomers, hexons and pentons. The capsomers interact with each other via the interweaved N-terminal arms of gp40 in addition to a tail-in-mouth joint along the three-fold symmetric axis, resulting in the assembly of capsid in a mortise-and-tenon pattern. The novel-fold cement protein gp47 sticks at the two-fold symmetric axis and further fixes the capsid. These findings provide structural insights into the assembly of cyanophages, and set up a platform to explore the mechanism of specific interactions and co-evolution with cyanobacteria.

Articles - 6j3q mentioned but not cited (2)

  1. Capsid Structure of Anabaena Cyanophage A-1(L). Cui N, Yang F, Zhang JT, Sun H, Chen Y, Yu RC, Chen ZP, Jiang YL, Han SJ, Xu X, Li Q, Zhou CZ. J Virol 95 e0135621 (2021)
  2. Viral Phrenology. Wilson DP, Roof DA. Viruses 13 2191 (2021)


Articles citing this publication (12)

  1. Genomic Analysis of Mic1 Reveals a Novel Freshwater Long-Tailed Cyanophage. Yang F, Jin H, Wang XQ, Li Q, Zhang JT, Cui N, Jiang YL, Chen Y, Wu QF, Zhou CZ, Li WF. Front Microbiol 11 484 (2020)
  2. Comparative genomic analysis of five freshwater cyanophages and reference-guided metagenomic data mining. Du K, Yang F, Zhang JT, Yu RC, Deng Z, Li WF, Chen Y, Li Q, Zhou CZ. Microbiome 10 128 (2022)
  3. Predicting the capsid architecture of phages from metagenomic data. Lee DY, Bartels C, McNair K, Edwards RA, Swairjo MA, Luque A. Comput Struct Biotechnol J 20 721-732 (2022)
  4. A Novel Wide-Range Freshwater Cyanophage MinS1 Infecting the Harmful Cyanobacterium Microcystis aeruginosa. Zhang S, He X, Cao L, Tong Y, Zhao B, An W. Viruses 14 433 (2022)
  5. A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability. Podgorski JM, Freeman K, Gosselin S, Huet A, Conway JF, Bird M, Grecco J, Patel S, Jacobs-Sera D, Hatfull G, Gogarten JP, Ravantti J, White SJ. Structure 31 282-294.e5 (2023)
  6. Confocal microscopy reveals alterations of thylakoids in Limnospira fusiformis during prophage induction. Zekri MA, Schagerl M, Schweichhart J, Lang I. Protoplasma 258 1251-1259 (2021)
  7. A Capsid Structure of Ralstonia solanacearum podoviridae GP4 with a Triangulation Number T = 9. Zheng J, Chen W, Xiao H, Yang F, Li X, Song J, Cheng L, Liu H. Viruses 14 2431 (2022)
  8. Fine structure and assembly pattern of a minimal myophage Pam3. Yang F, Jiang YL, Zhang JT, Zhu J, Du K, Yu RC, Wei ZL, Kong WW, Cui N, Li WF, Chen Y, Li Q, Zhou CZ. Proc Natl Acad Sci U S A 120 e2213727120 (2023)
  9. Structure and proposed DNA delivery mechanism of a marine roseophage. Huang Y, Sun H, Wei S, Cai L, Liu L, Jiang Y, Xin J, Chen Z, Que Y, Kong Z, Li T, Yu H, Zhang J, Gu Y, Zheng Q, Li S, Zhang R, Xia N. Nat Commun 14 3609 (2023)
  10. Ecological Dynamics of Broad- and Narrow-Host-Range Viruses Infecting the Bloom-Forming Toxic Cyanobacterium Microcystis aeruginosa. Morimoto D, Yoshida N, Sasaki A, Nakagawa S, Sako Y, Yoshida T. Appl Environ Microbiol 89 e0211122 (2023)
  11. Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals. Montaño ET, Nideffer JF, Brumage L, Erb M, Busch J, Fernandez L, Derman AI, Davis JP, Estrada E, Fu S, Le D, Vuppala A, Tran C, Luterstein E, Lakkaraju S, Panchagnula S, Ren C, Doan J, Tran S, Soriano J, Fujita Y, Gutala P, Fujii Q, Lee M, Bui A, Villarreal C, Shing SR, Kim S, Freeman D, Racha V, Ho A, Kumar P, Falah K, Dawson T, Enustun E, Prichard A, Gomez A, Khanna K, Trigg S, Pogliano K, Pogliano J. PLoS One 17 e0262354 (2022)
  12. Multi-year molecular quantification and 'omics analysis of Planktothrix-specific cyanophage sequences from Sandusky Bay, Lake Erie. McKindles KM, Manes M, Neudeck M, McKay RM, Bullerjahn GS. Front Microbiol 14 1199641 (2023)


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