Function and Biology

Ligand-triggered allosteric ADP release primes a plant NLR complex

Source organism: Arabidopsis thaliana
Biochemical function: protein binding
Biological process: defense response to bacterium
Cellular component: plasma membrane

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase ZRK1
The deposited structure of PDB entry 6j5w contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Serine/threonine-protein kinase ZRK1. Showing 1 copy in chain A [auth B].

PF00931
Domain description: NB-ARC domain
Occurring in:
  1. Disease resistance RPP13-like protein 4
The deposited structure of PDB entry 6j5w contains 1 copy of Pfam domain PF00931 (NB-ARC domain) in Disease resistance RPP13-like protein 4. Showing 1 copy in chain B [auth A].

PF18052
Domain description: Rx N-terminal domain
Occurring in:
  1. Disease resistance RPP13-like protein 4
The deposited structure of PDB entry 6j5w contains 1 copy of Pfam domain PF18052 (Rx N-terminal domain) in Disease resistance RPP13-like protein 4. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase ZRK1
IPR032675
Domain description: Leucine-rich repeat domain superfamily
Occurring in:
  1. Disease resistance RPP13-like protein 4
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Disease resistance RPP13-like protein 4
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase ZRK1
IPR045274
Domain description: Receptor-like kinase WAK-like
Occurring in:
  1. Serine/threonine-protein kinase ZRK1
IPR042197
Domain description: Apoptotic protease-activating factors, helical domain
Occurring in:
  1. Disease resistance RPP13-like protein 4
IPR002182
Domain description: NB-ARC
Occurring in:
  1. Disease resistance RPP13-like protein 4
IPR044974
Domain description: Disease resistance protein, plants
Occurring in:
  1. Disease resistance RPP13-like protein 4
IPR041118
Domain description: Disease resistance, N-terminal
Occurring in:
  1. Disease resistance RPP13-like protein 4
IPR038005
Domain description: Virus X resistance protein-like, coiled-coil domain
Occurring in:
  1. Disease resistance RPP13-like protein 4