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Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.

<div class='caption-title'>Super strong bindings of the KIBRA WW tandem to PY-motif containing proteins in cell growth control.</div>
<div class='caption-title'>Super strong bindings of the KIBRA WW tandem to PY-motif containing proteins functioning in cell growth control.</div>
<div class='caption-title'>ITC experiments showing the bindings of Dendrin PY23 or β-DG PY34 to KIBRA WW12, showing that the TRX-tag had minimal impact on the bindings of each of the two peptides to the KIBRA WW12 tandem.</div>
Lin Z, Yang Z, Xie R, Ji Z, Guan K, Zhang M
OpenAccess logo Elife 8 (2019)
Related entries: 6jjw, 6jjx, 6jjy, 6jjz, 6jk0, 6jk1

Cited: 23 times
EuropePMC logo PMID: 31486770

Abstract

WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain proteins in cell growth regulation. Here, we discovered that WW domain tandems of KIBRA and MAGI, but not YAP, bind to specific target proteins with extremely high affinity and exquisite sequence specificity. Via systematic structural biology and biochemistry approaches, we decoded the target binding rules of WW domain tandems from cell growth regulatory proteins and uncovered a list of previously unknown WW tandem binding proteins including β-Dystroglycan, JCAD, and PTPN21. The WW tandem-mediated target recognition mechanisms elucidated here can guide functional studies of WW domain proteins in cell growth and polarity as well as in other cellular processes including neuronal synaptic signaling.

Articles - 6j68 mentioned but not cited (1)

  1. Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity. Lin Z, Yang Z, Xie R, Ji Z, Guan K, Zhang M. Elife 8 e49439 (2019)


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  4. Reciprocal Regulation of Hippo and WBP2 Signalling-Implications in Cancer Therapy. Lim YX, Lin H, Seah SH, Lim YP. Cells 10 3130 (2021)

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  2. A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation. Hatterschide J, Brantly AC, Grace M, Munger K, White EA. J Virol 94 e01024-20 (2020)
  3. Multiphase coalescence mediates Hippo pathway activation. Wang L, Choi K, Su T, Li B, Wu X, Zhang R, Driskill JH, Li H, Lei H, Guo P, Chen EH, Zheng Y, Pan D. Cell 185 4376-4393.e18 (2022)
  4. Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor. Vargas RE, Duong VT, Han H, Ta AP, Chen Y, Zhao S, Yang B, Seo G, Chuc K, Oh S, El Ali A, Razorenova OV, Chen J, Luo R, Li X, Wang W. EMBO J 39 e102406 (2020)
  5. NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain. Liu S, Aldinger KA, Cheng CV, Kiyama T, Dave M, McNamara HK, Zhao W, Stafford JM, Descostes N, Lee P, Caraffi SG, Ivanovski I, Errichiello E, Zweier C, Zuffardi O, Schneider M, Papavasiliou AS, Perry MS, Humberson J, Cho MT, Weber A, Swale A, Badea TC, Mao CA, Garavelli L, Dobyns WB, Reinberg D. Mol Cell 81 4663-4676.e8 (2021)
  6. A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Lin Z, Xie R, Guan K, Zhang M. Cell Rep 32 108118 (2020)
  7. Two Hippo signaling modules orchestrate liver size and tumorigenesis. Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX. EMBO J 42 e112126 (2023)
  8. Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. Rheinemann L, Thompson T, Mercenne G, Paine EL, Peterson FC, Volkman BF, Alam SL, Alian A, Sundquist WI. J Biol Chem 297 100975 (2021)
  9. MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease. Romero-Masters JC, Grace M, Lee D, Lei J, DePamphilis M, Buehler D, Hu R, Ward-Shaw E, Blaine-Sauer S, Lavoie N, White EA, Munger K, Lambert PF. PLoS Pathog 19 e1011215 (2023)
  10. Modulating binding affinity, specificity, and configurations by multivalent interactions. Deng Y, Efremov AK, Yan J. Biophys J 121 1868-1880 (2022)
  11. Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier. Zhang H, Lin L, Liu J, Pan L, Lin Z, Zhang M, Zhang J, Cao Y, Zhu J, Zhang R. J Am Soc Nephrol 32 1946-1960 (2021)
  12. Structural insights into the role of the WW2 domain on tandem WW-PPxY motif interactions of oxidoreductase WWOX. Rotem-Bamberger S, Fahoum J, Keinan-Adamsky K, Tsaban T, Avraham O, Shalev DE, Chill JH, Schueler-Furman O. J Biol Chem 298 102145 (2022)
  13. Kinetic Regulation of the Mammalian Sterile 20-like Kinase 2 (MST2). Koehler TJ, Tran T, Weingartner KA, Kavran JM. Biochemistry 61 1683-1693 (2022)
  14. Molecular Interactions between Two LMP2A PY Motifs of EBV and WW Domains of E3 Ubiquitin Ligase AIP4. Seo MD, Seok SH, Kim JH, Choi JW, Park SJ, Lee BJ. Life (Basel) 11 379 (2021)
  15. Molecular determinants of TRAF6 binding specificity suggest that native interaction partners are not optimized for affinity. Halpin JC, Whitney D, Rigoldi F, Sivaraman V, Singer A, Keating AE. Protein Sci 31 e4429 (2022)
  16. Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease. Zhu QM, Hsu YH, Lassen FH, MacDonald BT, Stead S, Malolepsza E, Kim A, Li T, Mizoguchi T, Schenone M, Guzman G, Tanenbaum B, Fornelos N, Carr SA, Gupta RM, Ellinor PT, Lage K. Commun Biol 7 87 (2024)
  17. Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Chen L, Qian Z, Zheng Y, Zhang J, Sun J, Zhou C, Xiao H. Sci Adv 10 eadi7404 (2024)
  18. The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase. Bardwell AJ, Paul M, Yoneda KC, Andrade-Ludeña MD, Nguyen OT, Fruman D, Bardwell L. Biochem J BCJ20220493 (2023)


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