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Complex of GGTaseIII, farnesyl-Ykt6, and GGPP

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: endoplasmic reticulum to Golgi vesicle-mediated transport
Cellular component: plasma membrane

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EC 2.5.1.60: Protein geranylgeranyltransferase type II

Reaction catalysed:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Systematic name:
Geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
Alternative Name(s):
  • GGTaseII
  • Rab geranylgeranyltransferase
  • RabGGTase
  • Type II protein geranyl-geranyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00432
Domain description: Prenyltransferase and squalene oxidase repeat
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
The deposited structure of PDB entry 6j7x contains 5 copies of Pfam domain PF00432 (Prenyltransferase and squalene oxidase repeat) in Geranylgeranyl transferase type-2 subunit beta. Showing 5 copies in chain B.

PF01239
Domain description: Protein prenyltransferase alpha subunit repeat
Occurring in:
  1. Protein prenyltransferase alpha subunit repeat-containing protein 1
The deposited structure of PDB entry 6j7x contains 4 copies of Pfam domain PF01239 (Protein prenyltransferase alpha subunit repeat) in Protein prenyltransferase alpha subunit repeat-containing protein 1. Showing 4 copies in chain A.

PF00957
Domain description: Synaptobrevin
Occurring in:
  1. Synaptobrevin homolog YKT6
The deposited structure of PDB entry 6j7x contains 1 copy of Pfam domain PF00957 (Synaptobrevin) in Synaptobrevin homolog YKT6. Showing 1 copy in chain C.

PF13774
Domain description: Regulated-SNARE-like domain
Occurring in:
  1. Synaptobrevin homolog YKT6
The deposited structure of PDB entry 6j7x contains 1 copy of Pfam domain PF13774 (Regulated-SNARE-like domain) in Synaptobrevin homolog YKT6. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR002088
Domain description: Protein prenyltransferase, alpha subunit
Occurring in:
  1. Protein prenyltransferase alpha subunit repeat-containing protein 1
IPR001330
Domain description: Prenyltransferase alpha-alpha toroid domain
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
IPR010908
Domain description: Longin domain
Occurring in:
  1. Synaptobrevin homolog YKT6
IPR042855
Domain description: v-SNARE, coiled-coil homology domain
Occurring in:
  1. Synaptobrevin homolog YKT6
IPR045848
Domain description: YKT6, SNARE motif
Occurring in:
  1. Synaptobrevin homolog YKT6
IPR011012
Domain description: Longin-like domain superfamily
Occurring in:
  1. Synaptobrevin homolog YKT6
IPR045089
Domain description: Prenyltransferase subunit beta
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
IPR026873
Domain description: Geranylgeranyl transferase type-2 subunit beta
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
IPR008930
Domain description: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta

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