› 6j8v

X-ray diffraction
2.23Å resolution

Structure of MOEN5-SSO7D fusion protein in complex with ligand 2

Released:
DOI: 10.2210/pdb6j8v/pdb
PDB entry 6j8v coloured by chain, front view.
PDB entry 6j8v coloured by chain, side view.
PDB entry 6j8v coloured by chain, top view.
Source organisms:
Primary publication:
Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism.
Zhang L, Ko TP, Malwal SR, Liu W, Zhou S, Yu X, Oldfield E, Guo RT, Chen CC
Biochem Biophys Res Commun 511 800-805 (2019)
PMID: 30837154

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA-binding protein 7d; MoeN5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 343 amino acids
Theoretical weight: 37.58 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A010 (Residues: 1-260; Coverage: 100%)
  • Canonical: P39476 (Residues: 1-64; Coverage: 100%)
Gene names: SSO10610, moeN5, sso7d, sso7d-1
Sequence domains: 7kD DNA-binding domain
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:
Ligand FAR 1 x FAR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL15A1
Spacegroup: C222
Unit cell:
a: 137.856Å b: 217.336Å c: 104.159Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.225
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs.
Branco Santos et al. (2020)
2 other articles