6jhr

Electron Microscopy
3.68Å resolution

The cryo-EM structure of HAV bound to a neutralizing antibody-F6

Released:

Function and Biology Details

Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
NTP + H(2)O = NDP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
PDBe Complex ID:
PDB-CPX-209375 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 30.82 KDa
Source organism: Human hepatitis A virus Hu/Australia/HM175/1976
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 222 amino acids
Theoretical weight: 24.9 KDa
Source organism: Human hepatitis A virus Hu/Australia/HM175/1976
Capsid protein VP3 Chain: C
FAB Light Chain Chain: D
FAB Heavy Chain Chain: E

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.68Å
Relevant EMDB volumes: EMD-9828