› 6jj0

Solution NMR

NMR structure of the 1:1 complex of a carbazole derivative BMVC bound to c-MYC G-quadruplex

Released:
DOI: 10.2210/pdb6jj0/pdb
PDB entry 6jj0 coloured by chain, ensemble of 20 models, front view.
PDB entry 6jj0 coloured by chain, ensemble of 20 models, side view.
PDB entry 6jj0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition.
Liu W, Lin C, Wu G, Dai J, Chang TC, Yang D
OpenAccess logo Nucleic Acids Res 47 11931-11942 (2019)
PMID: 31740959

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120076 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
MycG4 Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 7.01 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand BO6 1 x BO6
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 43%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions.
Santos et al. (2021)
1 more

7 mentions without citation

Quadruplex Ligands in Cancer Therapy.
Sanchez-Martin et al. (2021)
6 more