EC 2.1.1.360: [Histone H3]-lysine(79) N-trimethyltransferase
Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(79) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(79)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(79) N(6)-trimethyltransferase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 6jma contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/6jma_2_A_Pfam_PF00125_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6jma</span> contains 2 copies of Pfam domain <span class='highlight'>PF00125 (Core histone H2A/H2B/H3/H4)</span> in <span class='highlight'>Histone H3.2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 6jma contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A. Showing 1 copy in chain E [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6jma_4_C_Pfam_PF00125_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6jma</span> contains 2 copies of Pfam domain <span class='highlight'>PF00125 (Core histone H2A/H2B/H3/H4)</span> in <span class='highlight'>Histone H2A</span>. Showing 1 copy in chain <span class='highlight'>E [auth C]</span>.")
![The deposited structure of PDB entry 6jma contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B 1.1. Showing 1 copy in chain F [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/6jma_5_D_Pfam_PF00125_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6jma</span> contains 2 copies of Pfam domain <span class='highlight'>PF00125 (Core histone H2A/H2B/H3/H4)</span> in <span class='highlight'>Histone H2B 1.1</span>. Showing 1 copy in chain <span class='highlight'>F [auth D]</span>.")
![The deposited structure of PDB entry 6jma contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A. Showing 1 copy in chain E [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6jma_4_C_Pfam_PF16211_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6jma</span> contains 2 copies of Pfam domain <span class='highlight'>PF16211 (C-terminus of histone H2A)</span> in <span class='highlight'>Histone H2A</span>. Showing 1 copy in chain <span class='highlight'>E [auth C]</span>.")
![The deposited structure of PDB entry 6jma contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain H [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/6jma_3_F_Pfam_PF15511_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6jma</span> contains 2 copies of Pfam domain <span class='highlight'>PF15511 (Centromere kinetochore component CENP-T histone fold)</span> in <span class='highlight'>Histone H4</span>. Showing 1 copy in chain <span class='highlight'>H [auth F]</span>.")
![The deposited structure of PDB entry 6jma contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain L [auth Y].](https://www.ebi.ac.uk/pdbe/static/entry/6jma_7_Y_Pfam_PF00240_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6jma</span> contains 1 copy of Pfam domain <span class='highlight'>PF00240 (Ubiquitin family)</span> in <span class='highlight'>Ubiquitin</span>. Showing 1 copy in chain <span class='highlight'>L [auth Y]</span>.")
![The deposited structure of PDB entry 6jma contains 1 copy of Pfam domain PF08123 (Histone methylation protein DOT1 ) in Histone-lysine N-methyltransferase, H3 lysine-79 specific. Showing 1 copy in chain K [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/6jma_6_X_Pfam_PF08123_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6jma</span> contains 1 copy of Pfam domain <span class='highlight'>PF08123 (Histone methylation protein DOT1 )</span> in <span class='highlight'>Histone-lysine N-methyltransferase, H3 lysine-79 specific</span>. Showing 1 copy in chain <span class='highlight'>K [auth X]</span>.")
InterPro annotations
IPR029063
Domain description:
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
Occurring in:
IPR004823
Domain description:
TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
Occurring in: