Function and Biology Details
Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(79) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(79)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domain:
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157217 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein AF-10
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 11.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Length: 98 amino acids
Theoretical weight: 11.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
P55197 (Residues: 699-782; Coverage: 8%)
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Molecule details ›
Chain: B
Length: 82 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Length: 82 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical: Q8TEK3 (Residues: 470-550; Coverage: 5%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL17U
Spacegroup:
I4122
Expression system: Escherichia coli BL21
