› 6jnr

X-ray diffraction
2.3Å resolution

RXRa structure complexed with CU-6PMN and SRC1 peptide.

Released:
DOI: 10.2210/pdb6jnr/pdb
PDB entry 6jnr coloured by chain, front view.
PDB entry 6jnr coloured by chain, side view.
PDB entry 6jnr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kawasaki M, Nakano S, Motoyama T, Yamada S, Watanabe M, Takamura Y, Fujihara M, Tokiwa H, Kakuta H, Ito S

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148728 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 243 amino acids
Theoretical weight: 27.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 224-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor coactivator 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 687-698; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

1 bound ligand:
Ligand WY5 2 x WY5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P43
Unit cell:
a: 64.39Å b: 64.39Å c: 111.168Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.238
Expression systems:
  • Escherichia coli
  • Not provided

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