› 6joi

X-ray diffraction
3.1Å resolution

Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization

Released:
DOI: 10.2210/pdb6joi/pdb
PDB entry 6joi coloured by chain, front view.
PDB entry 6joi coloured by chain, side view.
PDB entry 6joi coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liang L, Yan XE, Yun CH

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Platelet-derived growth factor receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 43.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P16234 (Residues: 550-973; Coverage: 33%)
  • Best match: P16234-3 (Residues: 550-706)
Gene names: PDGFR2, PDGFRA, RHEPDGFRA
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand 6T2 1 x 6T2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 52.757Å b: 73.992Å c: 103.706Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.244
Expression system: Spodoptera frugiperda

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