› 6jrl

X-ray diffraction
2.2Å resolution

Crystal structure of Drosophila alpha methyldopa-resistant protein/3,4-dihydroxyphenylacetaldehyde synthase

Released:
DOI: 10.2210/pdb6jrl/pdb
PDB entry 6jrl coloured by chain, front view.
PDB entry 6jrl coloured by chain, side view.
PDB entry 6jrl coloured by chain, top view.
Source organism: Drosophila melanogaster
Entry authors: Wei S, Vavrick CJ, Guan H, Liao C, Robinson H, Liang J, Wang D, Han Q, Li J

Function and Biology Details

Reaction catalysed: 
L-dopa + O(2) + H(2)O = 3,4-dihydroxyphenylacetaldehyde + CO(2) + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-538939 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3,4-dihydroxyphenylacetaldehyde synthase Chain: A
Molecule details ›
Chain: A
Length: 510 amino acids
Theoretical weight: 57.32 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P18486 (Residues: 1-510; Coverage: 100%)
Gene names: CG10501, amd, l(2)amd
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand LLP 1 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2221
Unit cell:
a: 72.469Å b: 117.307Å c: 139.801Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.267
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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