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Crystal structure of human MTH1 in complex with compound MI1006

Source organism: Homo sapiens
Biochemical function: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological process: response to cadmium ion
Cellular component: nuclear membrane

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EC 3.6.1.56: 2-hydroxy-dATP diphosphatase

Reaction catalysed:
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate
Systematic name:
2-hydroxy-dATP diphosphohydrolase
Alternative Name(s):
  • (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase
  • MTH1
  • MTH2
  • NUDT1
  • Oxidized purine nucleoside triphosphatase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00293
Domain description: NUDIX domain
Occurring in:
  1. Oxidized purine nucleoside triphosphate hydrolase
The deposited structure of PDB entry 6jvj contains 2 copies of Pfam domain PF00293 (NUDIX domain) in Oxidized purine nucleoside triphosphate hydrolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003563
Domain description: Oxidized purine nucleoside triphosphate
Occurring in:
  1. Oxidized purine nucleoside triphosphate hydrolase
IPR020476
Domain description: NUDIX hydrolase
Occurring in:
  1. Oxidized purine nucleoside triphosphate hydrolase
IPR000086
Domain description: NUDIX hydrolase domain
Occurring in:
  1. Oxidized purine nucleoside triphosphate hydrolase
IPR020084
Domain description: NUDIX hydrolase, conserved site
Occurring in:
  1. Oxidized purine nucleoside triphosphate hydrolase
IPR015797
Domain description: NUDIX hydrolase-like domain superfamily
Occurring in:
  1. Oxidized purine nucleoside triphosphate hydrolase

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