› 6jys

X-ray diffraction
1.7Å resolution

GII.13/21 noroviruses recognize glycans with a terminal beta-galactose via an unconventional glycan binding site

Released:
DOI: 10.2210/pdb6jys/pdb
PDB entry 6jys coloured by chain, front view.
PDB entry 6jys coloured by chain, side view.
PDB entry 6jys coloured by chain, top view.
Source organism: Alphatron virus
Primary publication:
GII.13/21 Noroviruses Recognize Glycans with a Terminal β-Galactose via an Unconventional Glycan Binding Site.
Cong X, Sun XM, Qi JX, Li HB, Chai WG, Zhang Q, Wang H, Kong XY, Song J, Pang LL, Jin M, Li DD, Tan M, Duan ZJ
OpenAccess logo J Virol 93 (2019)
PMID: 31118252

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
human norovirus P protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 308 amino acids
Theoretical weight: 33.91 KDa
Source organism: Alphatron virus
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: A0A509GV48 (Residues: 1-308; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: A2G, GAL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: A2G, GAL, NAG
Carbohydrate polymer
1 bound ligand:
Ligand THR 1 x THR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 60.728Å b: 99.695Å c: 221.824Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.165 0.188
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4

Quick links

Citations

2 citation in other articles

Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses.
Yang et al. (2019)
1 more

1 mention without citation

GII.13/21 Noroviruses Recognize Glycans with a Terminal β-Galactose via an Unconventional Glycan Binding Site.
Cong et al. (2019)